Intracellular trafficking of the β-secretase and processing of amyloid precursor protein
نویسندگان
چکیده
منابع مشابه
Amyloid precursor protein trafficking, processing, and function.
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid beta-protein (Abeta), the 38-43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identi...
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The E1 domain of APP and APLP2 determines α-secretase specificity Manuscript 6 Additional publications Jacobsen KT and Iverfeldt K Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors Exposure to the saturated free fatty acid palmitate alters BV-2 microglia inflammatory response Abstract The amyloid-β precursor protein (APP) has been widely studied due to ...
متن کاملSpecific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β-secretase inhibitors reduce Aβ levels, but mechanism-based side effects arise because they also inhibit β-cleavage of non-amyloid substrates like Neure...
متن کاملIntracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
BACKGROUND Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein secretory pathway and/or at plasma membrane, while immature APP (imAPP, N-glycosylated form) locates in ...
متن کاملHeparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
Cleavage of amyloid precursor protein (APP) by the Alzheimer's beta-secretase (BACE1) is a key step in generating amyloid beta-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP. We show that HS and heparin interact directly with BACE1 and inhibit in vitro proce...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2011
ISSN: 1521-6543
DOI: 10.1002/iub.512